DR. SITI AISYAH BINTI RAZALI
Faculty of Science & Marine Environment
aisyarazali@umt.edu.my
https://wise.umt.edu.my/aisyarazali
Executive Summary
Dr. Siti Aisyah Razali is a Senior Lecturer at Universiti Malaysia Terengganu specializing in bioinformatics driven drug discovery, with expertise in protein modeling, molecular docking, and molecular dynamics simulations. Her research targets viral and microbial pathogens affecting human and aquatic health, using in silico methods, including protein-ligand interaction analysis and virtual screening, to accelerate drug and vaccine discovery. She leads computational research projects in this space and supervises PhD and MSc candidates, with over 30 undergraduate research projects guided to date, many applying computational approaches to pharmaceutical problems. Her work bridges bioinformatics, pharmacology, and molecular biology toward translational drug development outcomes.
Expertise
LIFE SCIENCES
Biological Sciences
Biomolecular Sciences
Biomolecular Docking
Publications
Indexed Journal (Scopus & Wos)
Non-Indexed Journal
Books
Chapter In Books
Proceedings
RM738,194.00
Approved Grants
8
H-Index (Scopus)
10
Number of Projects
6
Total Postgraduate Students
PUBLICATIONS
Journals
Note: This list is compiled based on data from the last five years.
| No. | Article Title | Year | Journals | Indexing | Authorship |
|---|---|---|---|---|---|
| 1 | Combinatorial Treatment With ß-glucanase Enzyme And Chlorhexidine Induces Cysticidal Effects In Acanthamoeba Cyst | 2022 | Parasitology Research | Scopus | Corresponding Author |
| 2 | Synthesis, Anti-amoebic Activity And Molecular Docking Simulation Of Eugenol Derivatives Against Acanthamoeba Sp. | 2023 | Saudi Pharmaceutical Journal | Scopus | Co Author |
| 3 | Computationally Designed Anti-luxp Dna Aptamer Suppressed Flagellar Assembly- And Quorum Sensing-related Gene Expression In Vibrio Parahaemolyticus | 2022 | Biology | Scopus | Co Author |
| 4 | Multi-epitope Vaccine Design Against Grouper Iridovirus (giv) Using Immuno-bioinformatics Approach | 2024 | Malaysian Journal Of Fundamental And Applied Sciences | WoS | Corresponding Author |
| 5 | Molecular Docking And Pharmacokinetics Analysis Of Phytochemicals From Piper Caninum As Dengue Ns2b-ns3 Protease Inhibitors | 2024 | Journal Of Tropical Life Science | Scopus | Co Author |
| 6 | Exploring Ethynyl-based Chalcones As Green Semiconductor Materials For Optical Limiting Interests | 2024 | Spectrochimica Acta - Part A: Molecular And Biomolecular Spectroscopy | Scopus | Co Author |
| 7 | Marine Natural Products As Potential Inhibitors Against Pathogenic Streptococcus Agalactiae Using Molecular Docking Study For Human And Fish Disease Control | 2024 | Journal Of Sustainability Science And Management | Scopus | Corresponding Author |
| 8 | Riding The Wave Of Innovation: Immunoinformatics In Fish Disease Control | 2023 | Peerj | WoS | Main Author, Corresponding Author |
| 9 | Application Of Second-generation Sequencing (sgs) And Third Generation Sequencing (tgs) In Aquaculture Breeding Program | 2022 | Aquaculture | Scopus | Co Author |
| 10 | Discovery Of Azaleatin As A Potential Allosteric Inhibitor For Dengue Ns2b-ns3 Protease Using In Vitro And In Silico Studies | 2024 | Journal Of Biomolecular Structure & Dynamics | WoS | Co Author |
| 11 | Multi-epitope Vaccine Design Against Grouper Iridovirus (giv) Using Immunobioinformatics Approach | 2024 | Malaysian Journal Of Fundamental And Applied Sciences | Scopus | Corresponding Author |
| 12 | Evaluation Of Methoxyflavones As Dengue Ns2b–ns3 Protease Inhibitors: An In Silico And In Vitro Studies | 2025 | Molecular Diversity | Scopus | Co Author |
| 13 | Discovery Of Azaleatin As A Potential Allosteric Inhibitor For Dengue Ns2b-ns3 Protease Using In vitro And In Silico Studies | 2024 | Journal Of Biomolecular Structure And Dynamics | Scopus | Co Author |
| 14 | In Silico Protein Interaction Analysis Of Dengue Virus Non-structural 2a And Human Potassium Channel Kv1.3 | 2024 | Jurnal Teknologi-sciences & Engineering | WoS | Co Author |
| 15 | Bioassessment Of Acetylide-imine In Acanthamoeba Sp. Through In Vitro And In Silico Investigations For Its Environmental Contamination Implications From Electronic Waste | 2025 | Asm Science Journal | Scopus | Co Author |
| 16 | Cell-based And Computational Toxicity Profiling Of Thiourea And Imine Derivatives In Acanthamoeba Sp. As Environmental Bioindicators For Potential Optoelectronic Applications | 2026 | Chemosphere | Scopus | Co Author |
| 17 | Evaluation Of Methoxyflavones As Dengue Ns2b-ns3 Protease Inhibitors: An In Silico And In Vitro Studies | 2025 | Molecular Diversity | WoS | Co Author |
| 18 | Molecular Docking And Simulation Studies Of Chloroquine, Rimantadine And Cap-1 As Potential Repurposed Antivirals For Decapod Iridescent Virus 1 (div1) | 2023 | Fish And Shellfish Immunology Reports | Scopus | Corresponding Author |
Books
| No. | Book Title | Year | Publisher | Authorship |
|---|
Chapter In Books
| No. | Book Title | Chapter Title | Year | Publisher | Authorship |
|---|
Proceeding
| No. | Article Title | Year | Proceeding | Indexing | Authorship |
|---|---|---|---|---|---|
| 1 | In Silico Analysis Of Gracilaria Changii Proteins For Potential Bioactive Peptides | 2022 | 3rd International Conference On Integrated Coastal Management And Marine Biotechnology 2021, Icmmbt 2021 | Scopus | Co Author |
RESEARCH GRANTS
Note: This list is compiled based on data from the last five years.
| No. | Grant Title | Role | Level | Funder | Value (RM) | Status |
|---|---|---|---|---|---|---|
| 1 | Unravelling The Role And Performance Of Thiazole¿¿¿chalcone Metalloorganic Against Trophozoite And Cyst Stages Of A Clinical Acanthamoeba Isolate: In Vitro And In Silico Analyses | Co-Researcher | University | UMT | RM30,000.00 | In Progress |
| 2 | Featuring Marine And Freshwater Cystic Acanthamoeba As Bioindicators In Assessing The Safety Measures Of Synthesized Polycyclic Aromatic Hydrocarbons (pahs)-based Chalcones And The Implications Of Potential E-waste Via Integrated Proteomics And In Silico Analyses | Co-Researcher | University | UMT | RM40,000.00 | In Progress |
| 3 | Elucidating The Non-steroidal Anti-inflammatory Drugs (naproxen) Degradation Mechanism By Thermotolerant Bacteria Isolated From Sewage Wastewater Plants As A Green Technology To Remediate Pharmaceutical-derived Pollutants | Co-Researcher | National | KEMENTERIAN PENDIDIKAN TINGGI (KPT) | RM143,800.00 | In Progress |
| 4 | Bioindicator-based Assessment Of Mixed Conjugated Moieties Of The Functional Molecules Towards Acanthamoeba Sp. In The Context Of E-waste Pollution: In Vitro And In??silico??studies | Co-Researcher | University | UMT | RM20,000.00 | In Progress |
| 5 | Computational Analysis Of Grouper Iridovirus Drug Discovery Using Chem-bioinformatic Approaches | Project Leader | National | Kementerian Pendidikan Malaysia (KPM) | RM115,200.00 | Completed |
| 6 | Computational Analysis Of Grouper Iridovirus Drug Discovery Using Chem-bioinformatic Approaches | Project Leader | National | Kementerian Pengajian Tinggi (KPT) | RM115,000.00 | Completed |
| 7 | Identification Of Methoxyflavone From Piper Caninum As Dengue Ns2b-ns3 Protease Inhibitors By Molecular Docking And In Vitro Assay | Co-Researcher | National | Kementerian Pengajian Tinggi (KPT) | RM84,194.00 | Completed |
| 8 | Multi-epitope Vaccine Design Against Grouper Iridovirus (giv) Using Immuno-bioinformatics And Structural Analysis | Project Leader | University | UMT | RM20,000.00 | Completed |
| 9 | Multi-epitope Vaccine Design Against Grouper Iridovirus (giv) Using Immuno-bioinformatics And Structural Analysis | Project Leader | University | Universiti Malaysia Terengganu (UMT) | RM20,000.00 | In Progress |
| 10 | Elucidation Of The Potential Role Of Human Voltage-gated Potassium Channel Kv1.3 In Modulating Dengue Virus Infection | Co-Researcher | National | Kementerian Pengajian Tinggi (KPT) | RM150,000.00 | In Progress |
TEACHING
Note: This list is compiled based on data from the last five years.
| No. | Subject Name | Degree Level |
|---|---|---|
| 1 | Biometry | Bachelor |
| 2 | Cell And Molecular Biology | Bachelor |
| 3 | Contemporary Issues In Biology | Bachelor |
| 4 | Ai-driven Innovations In Biology | Bachelor |
| 5 | Bioinformatics | Bachelor |
POSTGRADUATE STUDENT
Note: This list is compiled based on data from the last five years.
| No. | Student Name | Degree | Status |
|---|---|---|---|
| 1 | Irdeana Marsha Binti Baharuddin | Doctor of Philosophy | Ongoing |
| 2 | Farah Najihah Binti Razali | Doctor of Philosophy | Ongoing |
| 3 | Nur Farhana Binti Mustafa | Master | Completed |
| 4 | Nur Farahin Binti Ishak | Master | Completed |
| 5 | Thivyan A/l Manisekaran | Master | Completed |
| 6 | Muhammad Arif Naqiuddin Bin Nasir | Master | Ongoing |
INTELLECTUAL PROPERTIES
Note: This list is compiled based on data from the last five years.
| No. | IP Title | IP Type | IP Status | Reference ID | Year |
|---|---|---|---|---|---|
| 1 | A Comprehensive Computational Pipeline For Therapeutic Compound Identification Against Fish And Marine Organism Pathogens Using Open-sources Molecular Docking | Copyright | Awarded | LY2024W08541 | 2024 |
CONSULTANCY
Note: This list is compiled based on data from the last five years.
| No. | Title | Date | Level | Client Name |
|---|---|---|---|---|
| 1 | Hands-on Workshop:structural Bioinformatics | 01/02/2024 - 01/12/2024 | National | Umt Holding |
KNOWLEDGE TRANSFER
Note: This list is compiled based on data from the last five years.
| No. | Title | Year | Level | Collaborator | Funder |
|---|
AWARDS
| No. | Name of Awards/Recognition | Awarding Institution | Year Awarded | Level |
|---|---|---|---|---|
| 1 | Bg-chlorhex: Par Glycohydrolase Suppressor | Uc Tati | 2023 | National |
| 2 | Best Oral Presenter | Universitas Gadjah Mada, Yogyakarta, Indonesia | 2023 | International |
| 3 | Betac:beta-glucanase Enzyme And Chlorhexidine As Acanthamoeba Cysticidal Agent | Kementerian Pengajian Tinngi | 2022 | International |
